Cryptophycin 中文
WebCryptophycin Affinity Labels: Synthesis and Biological Activity of a Benzophenone Analogue of Cryptophycin-24. クリプトフィシン親和性標識:クリプトフィシン-24のベンゾフェノン … WebMay 11, 2000 · An efficient and highly stereoselective synthesis of cryptophycin B (2), a potent cytotoxic agent, is described. The ester-derived titanium-enolate-mediated syn-aldol reaction was employed to generate the stereocenters C(5) and C(6). The route is convergent and provides a convenient access to the synthesis of structural variants of cryptophycin B …
Cryptophycin 中文
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Web WebCryptophycins are a class of 16-membered highly cytotoxic macrocyclic depsipeptides isolated from cyanobacteria. The biological activity is based on their ability to interact with tubulin. They interfere with microtubule dynamics and prevent microtubules from forming correct mitotic spindles, which causes cell-cycle arrest and apoptosis.
WebJun 17, 2024 · Methods: A peptide-drug conjugate (ER-472) composed of Cltx linked to cryptophycin as warhead was developed as a tool to probe the molecular target and mechanism of action of Cltx, using multiple xenograft models. Results: Neuropilin-1 (NRP1), an endocytic receptor on tumor and endothelial cells, was identified as a novel Cltx target, … WebCryptophycin is a new anticancer drug discovered from micro-algae by researchers of the University of Hawaii and Wayne State University. Some of the cryptophycin analogs are …
The crytophycins represent an extraordinarily potent class of cyanophyte-derived cytotoxins. As a consequence of their potent pharmacological activity, these compounds … WebNov 1, 2006 · The unit A trifluoromethyl-modified cryptophycin proved to be highly active against KB-3-1 cells and exhibited an IC50 value in the low picomolar range, but the replacement of the 3-chloro-4-methoxyphenyl-substituent in unit B by a pentafluorophenyl moiety resulted in a significant loss of activity. Expand
Web广西大学化学化工学院 教授 ，2003年11月至2005年10月，作为博士后在美国 夏威夷大学 从事抗癌活性化合物Cryptophycin新合成工艺及其 构效关系 研究。. 1991年9月至1994年12月，在 沈阳药科大学 学习,获得 药物化学专业 理学博士学位。. 1988年9月至1991年7月，在 沈 …
WebAug 4, 1998 · Cryptophycin-52 (LY355703) (Fig. 1) is a new synthetic member of the cryptophycin family that is currently undergoing clinical evaluation (D.W., M. M. Wagner, D. C. Paul, M.A.J., L.W., and C. Shih, unpublished work).It was selected as a clinical candidate from an extensive series of cryptophycin analogs based on its potency, breadth of activity … lite and easy nswWebCryptophycin-55/52 based antibody-drug conjugates: Synthesis, efficacy, and mode of action studies クリプトフィシン-55/52に基づく抗体-薬物複合体:合成,有効性および作用 … lite and easy menu australiaWebFeb 6, 2007 · Cryptophycin 1 is a new cytotoxic antimicrotubule agent with excellent antitumor activity. The methods of Sackett (Biochemistry, 34, 7010-7019, 1995), utilizing the selective and specific ... lite and easy new spring menuWebCryptophycin-52 (Cp-52) is potentially the most potent anticancer drug known, with IC50 values in the low picomolar range, but its binding site on tubulin and mechanism of action are unknown. Here, we have determined the binding site of Cp-52, and its parent compound, cryptophycin-1, on HeLa tubulin, to a resolution of 3.3 Å and 3.4 Å, respectively, by cryo … imperial roofing chinnorWebTraductions en contexte de "par ailleurs être administrés" en français-anglais avec Reverso Context : Ces principes actifs peuvent par ailleurs être administrés selon n'importe quelle voie d'administration préférée, notamment par voie orale, intraveineuse, et parentérale. imperial roofing company fort myersWebCryptophycin is the cryptophycins are a family of 16-membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. The mechanism of anticancer activity … lite and easy menu victoriaWebThis invention concerns methods of treating a patient diagnosed with glioblastoma comprising administering to said patient a therapy comprising an effective amount of an anti-VEGF antibody and a chemotherapeutic. imperial roofing west union iowa