WebJan 28, 2011 · GRK Phosphorylation of Receptors for β-Arrestin Recruitment GRK-phosphorylation of receptors is not sufficient for desensitization, but rather serves to create high affinity sites to promote the recruitment of the cytoplasmic accessory proteins, arrestins, and target the receptors for internalization via clathrin-coated pits. WebThe sequence of GRK2 fits strongly the consensus phosphorylation motif for proline-directed kinases, in which a Pro residue at the −1 position relative to the phosphorylation site is absolutely required along with a weak preference for Pro and other aliphatic residues at the −2 position.
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WebApr 15, 2024 · GRK phosphorylation has been proposed to a key process that controls the balance between G protein- and β-arrestin-mediated signaling 47. WebJan 25, 2005 · Because G protein-coupled receptor kinase (GRK) phosphorylation of such receptors is generally a prerequisite for β-arrestin binding, we studied the roles of different GRKs in promoting β-arrestin-mediated extracellular signal-regulated kinase (ERK) activation by a typical seven-transmembrane receptor, the Gs-coupled V2 vasopressin … community policing partnership
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WebMay 14, 2024 · We found that GRK-mediated phosphorylation involves several serine and threonine residues on the C-terminus and ICL3. Mutation of these residues to alanine or valine, respectively, abolishes DA-induced D1R phosphorylation and severely impairs β-arrestin recruitment, but causes little effect on G protein-mediated signaling. WebNational Center for Biotechnology Information WebThis GRK-mediated phosphorylation was then considered to simply attract β-arrestins to the active state receptor to further inhibit G protein-mediated signaling, through the so-called process of homologous receptor … easy to tie fishing knot