Lxr agonist gw3965
WebGW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM in cell-free assays, respectively. GW3965 recruits the steroid receptor … Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆
Lxr agonist gw3965
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WebBiological Activity for GW 3965 hydrochloride. GW 3965 hydrochloride is a selective, orally active non-steroidal agonist for the liver X receptor (LXR). In cell-based reporter gene assays, acts as a full agonist of hLXR α and hLXR β (EC 50 values are 190 and 30 nM respectively). Reduces angiotensin II-mediated increases in blood pressure; up ... http://shiji.cnreagent.com/s/sv274538.html
WebThe heterodimer will be activated by an LXR agonist or a RXR agonist. After activation, LXR will binds to LXR response element and regulated related gene expression.[2] GW3965 can result in promotion of tumor cell death and inhibition of cell growth in GBM cells at 2μM. GW3965 treatment at 2μM can significantly promote increases in mRNA ... WebSupporting: 2, Contrasting: 1, Mentioning: 64 - To study the mechanism of interleukin-6 (IL-6) induction of human C-reactive protein (CRP) gene expression, we have utilized a human hepatoma (PLC/PRF/5) cell culture system to analyze the trans-acting factors which bind to the 300 bp 5'-flanking region of human CRP gene. In vitro gel mobility shift analyses and …
WebHerein, enhanced proresolving activity of polymeric nanoparticles (NPs) containing the synthetic LXR agonist GW3965 (LXR-NPs) is demonstrated, developed from a combinatorial library of more than ... Web22 oct. 2013 · Interestingly, activation of LXR by its agonists GW3965 and T0901317 has been shown to significantly inhibit tumor growth in GBM, breast, and prostate cancers [24,25,29,125]. Additionally, activation of LXR by GW3965 downregulates LDLR levels through upregulating a ubiquitin ligase E3 known as inducible degrader of LDLR (Idol), …
WebWe previously reported that pretreatment of rats with the liver X receptor (LXR) agonist GW3965 reduced the liver injury associated with endotoxemia and attenuated the …
WebWe previously reported that pretreatment of rats with the liver X receptor (LXR) agonist GW3965 reduced the liver injury associated with endotoxemia and attenuated the production of TNF-alpha by rat Kupffer cells. Here, we examine the dose-dependent effect of GW3965 on liver injury and cytokine production in a rat model of endotoxemia and ... roary the racing car zippeeWebCustomer Review. GW3965 is a potent, selective liver X receptor (LXR) agonist with EC50 s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively [1] [2] [3] . GW3965 … snl tic tac toeWeb17 sept. 2013 · LXR-mediated effects on NF-κB have also been reported in other cell types. Cheng et al. 32 reported decreased p65 expression following ischaemic brain injury in rats treated with the LXR agonist GW3965, and Wu et al. 33 reported decreased NF-κB activity in cardiomyocytes as a result of LXR activation with T0901317. Studies have also shown ... snl tight pantsWeb27 apr. 2013 · T0901317 and GW3965 are the synthetic ligands that activate endogenous LXRs [ 14 – 16 ].These two nonsteroid synthetic LXR agonists can cross the BBB and exert specific actions on LXR receptors [ 17, 18 ]. T0901317 is a potent and selective agonist for both LXRα and LXRβ, with an EC 50 of about 50 nM [ 19 ]. snl tim meadows oj simpson i did itWeb1 sept. 2015 · In macrophages, the GW3965-dependent repression of pro-inflammatory gene expression in response to LPS is regulated by the LXR-mediated stabilization of … snl tina feyWeb15 nov. 2024 · An LXR agonist GW3965 (10 mg/kg/day, i.p.) was administered to animals for last seven days. Key findings: GW3965 treatment reduced systolic blood pressures in … snl timothyWebTo further validate the ability of LXR agonists to repress gene expression through direct LXR binding, we treated WT mice with GW3965 and measured gene expression by qPCR (Fig. 5C ... The pharmacological repression by LXR agonist was dependent on the presence of Foxa2 for half of the genes showing direct ligand-dependent repression from our ... snl tim meadows skits