Web5 aug. 2024 · Retinoic acid (RA), also known as all-trans retinoic acid (ATRA), is an important metabolite of vitamin A that mediates the functions of vitamin A required for growth and development, which is mainly attributed to gene transcription induced by ATRA [1].Vitamin A, which exhibits high biological efficacy, as has been known for nearly a … Web24 apr. 2024 · All-trans retinoic acid (ATRA) plus arsenic trioxide (ATO) is a well-established treatment for patients with standard-risk APL, but it is not well defined for …
Trisenox European Medicines Agency
Web11 apr. 2024 · As a general rule, treatment of patients with ATRA-sensitive variants should include this agent in combination with anthracycline-based chemotherapy, whereas in … Web30 aug. 2011 · After testing revealed complete morphologic, cytogenetic, and molecular remission of the APL, he was started on consolidation therapy, which includes short cycles of arsenic chemotherapy with … flight fd
Arsenic trioxide for treating acute promyelocytic leukaemia
Web11 mrt. 2024 · Acute leukemia during pregnancy is rare (1 for 100000 pregnancies). The association of arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) is known as the best therapy in standard-risk acute promyelocytic leukemia (APL). We describe the first case of a pregnancy with ATRA and ATO reported in the literature. In March 2024 at the … Web26 mei 2024 · In a phase 3, multicentre, non-inferiority trial comparing all-trans-retinoic acid (ATRA) plus chemotherapy with ATRA plus arsenic trioxide in newly diagnosed low-to-intermediate risk APL patients (Study APL0406; see also section 5.1), serious adverse reactions including hepatic toxicity, thrombocytopenia, neutropenia and QTc prolongation … WebATRA plus arsenic trioxide or ATRA plus mitoxantrone are alternative regimens for high-risk patients who are unable to tolerate anthracyclines, but these are not routinely used in this setting. Heuser M, Ofran Y, Boissel N, et al. Acute myeloid leukaemia in adult patients: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. chemistry a level tutors near me